Research on Hereditability of Gastric Cancer in Wuwei City
نویسندگان
چکیده
AIM To explore hereditability of gastric cancer in Wuwei city. METHODS A case-control study was used to investigate 251 gastric cancer families located in Wuwei city. Li-Mantel-Gan and Falconer regression methods were used to calculate segregation ratios and hereditability. RESULTS The segregation ratio in Wuwei families was 0.0774, the hereditability of class I kinfolks and class II kinfolks were respectively 22.91% and 20.07%. CONCLUSION The segregation ratio of gastric cancer in Wuwei was significantly lower than for mono-genetic diseases (0.25), corresponding better with a model of polygenetic diseases. The genetic susceptibility factor accounted for about 1/5-1/4 in the formation of gastric cancer familial aggregation. Mi DH, Chen XP, Luo HZ Research on hereditability of gastric cancer in Wuwei city.
منابع مشابه
Cancer Incidence and Mortality Survey in Wuwei, Gansu Province, Northwestern China from 2003 to 2012: A Retrospective Population-based Study
BACKGROUND Population-based cancer registry collects the data on cancer incidence and mortality deaths from covered population to describe and survey the epidemics in certain areas. The aim of this study was to estimate the cancer incidence and mortality in Wuwei, Gansu province, Northwestern China from 2003 to 2012. The goal is to better understand cancer distribution and long-term development...
متن کاملRelationship of Social Risk Factors and Helicobacter pylori Infection with Pathological Characteristics of Gastric Carcinoma
Background: Cancer is the priority of the World Health Organization (WHO) and a serious challenge in death of human untimely. Assessment of social and physiological risk factors in gastric carcinoma patients can reveal the reasons of high prevalence gastric carcinoma in Sanandaj city. Methods: In a descriptive cross-sectional study, the variables of sex, age, education, occupation and active H...
متن کاملFraction Bioactivity Screening of Mulberry Leaf and Two Flavonoids in Combination with Cisplatin on Human Gastric Adenocarcinoma Cells
The successful therapy strategy of gastric cancer is defined as devastating of the cancerous cells without exposing systematic toxicity and undesirable side effects. One strategy to overcome cancer treatment related difficulties could be combination therapy with natural products with anticancer drugs to introduce effective antitumor effects in addition to reduction of undesirable side effects. ...
متن کاملFraction Bioactivity Screening of Mulberry Leaf and Two Flavonoids in Combination with Cisplatin on Human Gastric Adenocarcinoma Cells
The successful therapy strategy of gastric cancer is defined as devastating of the cancerous cells without exposing systematic toxicity and undesirable side effects. One strategy to overcome cancer treatment related difficulties could be combination therapy with natural products with anticancer drugs to introduce effective antitumor effects in addition to reduction of undesirable side effects. ...
متن کاملPrevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive Disorders
Background and Aims: Helicobacter pylori is the main cause of various gastroduodenal diseases. It is estimated that app roximately, more than half of the adult population in developed countries and 90% of people in developing countries infected with H. pylori. H. pylori infection may be related to Genetic of virulence factors and environmental factors. The aim of this study was to assess of fre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2006